Depression, anxiety attacks, hypochondriasis, alcoholism, compulsive gambling, insomnia, stress-o-holism, these are all names given to symptoms of overstress, or to the major Pick-Me-Up that the person is using for self-medication. We now know that each of these is not a disease in-and-of itself but may be a result of Happy Messenger malfunction, and the person's largely futile efforts to self-medicate with Pick-Me-Up's or Put Me-Down's.